Invitrogen™ SOCS7 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552079

Catalog No. PIPA552079

Description

Immunogen sequence: LETNSCSEEE LSSPGRGGGG GGRLLLQPPG PELPPVPFPL QDLVPLGRLS RGEQQQQQQQ QPPPPPPPPG PLRPLAGPSR KGSFKIRLSR LFRTKSCNGG SGGGDGTGKR PSGELAASAA SLTDMGGSAG RELDAGRKPK LTR Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.

SOCS7 regulates signaling cascades probably through protein ubiquitination and/or sequestration. SOCS7 functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. SOCS7 inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. SOCS7 may be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Specifications

• Antigen: SOCS7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SOCS7
• Gene Alias: 2310063P06Rik; C85125; Cish7; NAP4; NAP-4; Nck, Ash and phospholipase C binding protein; nck, Ash and phospholipase C gamma-binding protein; NCKAP4; Nck-associated protein 4; SH2 domain containing SOCS box protein SOCS7; SOCS6; SOCS7; SOCS-7; suppressor of cytokine signaling 6; suppressor of cytokine signaling 7
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 30837
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O14512
• Gene Symbols: SOCS7
• Immunogen: Recombinant protein corresponding to Human SOCS7. Recombinant protein control fragment (Product #RP-102085).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG