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Invitrogen™ SOCS7 Polyclonal Antibody
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Catalog No. PIPA552079
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100 μL
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PIPA552079 100 μL
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Catalog No. PIPA552079 Supplier Invitrogen™ Supplier No. PA552079
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LETNSCSEEE LSSPGRGGGG GGRLLLQPPG PELPPVPFPL QDLVPLGRLS RGEQQQQQQQ QPPPPPPPPG PLRPLAGPSR KGSFKIRLSR LFRTKSCNGG SGGGDGTGKR PSGELAASAA SLTDMGGSAG RELDAGRKPK LTR Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.

SOCS7 regulates signaling cascades probably through protein ubiquitination and/or sequestration. SOCS7 functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. SOCS7 inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. SOCS7 may be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SOCS7
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SOCS7
Gene Accession No. O14512
Gene Alias 2310063P06Rik; C85125; Cish7; NAP4; NAP-4; Nck, Ash and phospholipase C binding protein; nck, Ash and phospholipase C gamma-binding protein; NCKAP4; Nck-associated protein 4; SH2 domain containing SOCS box protein SOCS7; SOCS6; SOCS7; SOCS-7; suppressor of cytokine signaling 6; suppressor of cytokine signaling 7
Gene Symbols SOCS7
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SOCS7. Recombinant protein control fragment (Product #RP-102085).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 30837
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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