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SOD2 Monoclonal Antibody (OTI1H6), TrueMAB™, OriGene
SDP

Catalog No. 501672995
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50-167-2995 100 μL
50-254-1938 30 μL
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Catalog No. 50-167-2995 Supplier OriGene Supplier No. TA501887
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Description

Mouse Monoclonal Antibody

Superoxide dismutase (SOD2) is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS). SOD catalyzes the dismutation reaction of superoxide radical anion (O2) to hydrogen peroxide, which is then catalyzed to innocuous O2 and H2O by glutathione peroxidase and catalase. Several classes of SOD have been identified. These include intracellular copper, zinc SOD (Cu, Zn-SOD/SOD-1), mitochondrial manganese SOD (Mn-SOD/SOD-2) and extracellular Cu, Zn-SOD (EC-SOD/SOD-3). SOD1 is found in all eukaryotic species as a homodimeric 32 kDa enzyme containing one each of Cu and Zn ion per subunit. The manganese containing 80 kDa tetrameric enzyme SOD2, is located in the mitochondrial matrix in close proximity to a primary endogenous source of superoxide, the mitochondrial respiratory chain. SOD3 is a heparin-binding multimer of disulfide-linked dimers, primarily expressed in human lungs, vessel walls and airways. SOD4 is a copper chaperone for superoxide dismutase (CCS), which specifically delivers Cu to copper/zinc superoxide dismutase. CCS may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor.

Specifications

Antigen SOD2
Applications Western Blot
Classification Monoclonal
Clone OTI1H6
Concentration 0.65 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene SOD2
Gene Accession No. P04179, P54712
Gene Alias IPO-B, IPOB, MNSOD, MVCD6, Mn-SOD
Gene Symbols SOD2
Host Species Mouse
Immunogen Full length human recombit protein of human SOD2 produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 476258, 6648
Target Species Canine, Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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