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R&D Systems™ Sonidegib
SDP

Catalog No. RD10195055 Shop All Novus Products
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RD10195055 10 mg
78-265-0 50 mg
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Catalog No. RD10195055 Supplier R&D Systems™ Supplier No. 7826/10

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Description

A Tocris product, part of R&D Systems. Potent Smoothened receptor antagonist

Sonidegib is a potent Smoothened (Smo) receptor antagonist (IC50 values are 1.3 nM and 2.5 nM at mouse and human receptors, respectively). Inhibits growth of a variety of tumor types including basal cell carcinoma, small cell lung cancer and medulloblastoma. Sonidegib inhibits Hh pathway in CD34+ chronic myeloid leukemia cells; it reduces both the number of cells and self-renewal ability. Brain penetrant and orally bioavailable.

Specifications

Chemical Name or Material rel-N-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxamide
CAS 956697-53-3
Quantity 10 mg
Product Line Tocris
Target Smoothened
Molecular Formula C26H26F3N3O3
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