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Tocris Bioscience™ Sonidegib
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Catalog No. 782650
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50 mg
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Catalog No. Quantity
78-265-0 50 mg
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Catalog No. 78-265-0 Supplier Tocris Bioscience™ Supplier No. 7826/50
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Description

Potent Smoothened receptor antagonist

Sonidegib is a potent Smoothened (Smo) receptor antagonist (IC50 values are 1.3 nM and 2.5 nM at mouse and human receptors, respectively). Inhibits growth of a variety of tumor types including basal cell carcinoma, small cell lung cancer and medulloblastoma. Sonidegib inhibits Hh pathway in CD34+ chronic myeloid leukemia cells; it reduces both the number of cells and self-renewal ability. Brain penetrant and orally bioavailable.

Specifications

Chemical Name or Material rel-N-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxamide
CAS 956697-53-3
Quantity 50 mg
Target Smoothened
Molecular Formula C26H26F3N3O3
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