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Invitrogen™ Sorcin Polyclonal Antibody
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Catalog No. PIPA567302
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100 μL
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PIPA567302 100 μL
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Catalog No. PIPA567302 Supplier Invitrogen™ Supplier No. PA567302
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LNGWRQHFISF DTDRSGTVDP QELQKALTTM GFRLSPQAVN SIAKRYSTNG KITFDDYI Highest antigen sequence identity to the following orthologs - mouse 93%, rat 92%.

Sorcin is a 198 amino acid, soluble, resistance-related, calcium-binding cytosolic protein belonging to the penta-EF hand (PEF) family of calcium binding proteins and contains 4 EF-hand calcium-binding motifs. Human Sorcin is known to share 95% sequence identity with hamster Sorcin. It is known to associate with the sarcolemmal proteins Annexin VII, cardiac ryanodine receptors and L-type Ca2+ channels and thus influence the intracellular Ca (2+)-homeostasis. It is also important in the regulation of intracellular Ca2+ cycling and Ca2+ influx pathways in the heart and skeletal muscle during excitation-contraction. It is overproduced in many multi-drug resistance (MDR) cells and regulates cell apoptosis pathways, thus acting as a new MDR marker for prognosis of acute myeloid leukemia (AML) and a good target for anti-MDR drug development.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Sorcin
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Sri
Gene Accession No. P30626
Gene Alias 22 kDa protein; 2210417O06Rik; 2900070H08Rik; calcium binding protein amplified in mutlidrug-resistant cells; CP22; CP-22; H_RG167B05.1; SCN; Sor; Sorcin; SRI; V19
Gene Symbols Sri
Host Species Rabbit
Immunogen Recombinant Human Sorcin. Recombinant protein control fragment (Product #RP-105582).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6717
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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