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Sorcin Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501989412
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100 μL
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50-198-9412 100 μL
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Catalog No. 50-198-9412 Supplier Bioss Supplier No. BS9871R
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Description

Rabbit Polyclonal Antibody

Sorcin is a 198 amino acid, soluble, resistance-related, calcium-binding cytosolic protein belonging to the penta-EF hand (PEF) family of calcium binding proteins and contains 4 EF-hand calcium-binding motifs. Human Sorcin is known to share 95% sequence identity with hamster Sorcin. It is known to associate with the sarcolemmal proteins Annexin VII, cardiac ryanodine receptors and L-type Ca2+ channels and thus influence the intracellular Ca (2+)-homeostasis. It is also important in the regulation of intracellular Ca2+ cycling and Ca2+ influx pathways in the heart and skeletal muscle during excitation-contraction. It is overproduced in many multi-drug resistance (MDR) cells and regulates cell apoptosis pathways, thus acting as a new MDR marker for prognosis of acute myeloid leukemia (AML) and a good target for anti-MDR drug development.

Specifications

Antigen Sorcin
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Sri
Gene Accession No. P30626
Gene Alias 22 kDa protein; 2210417O06Rik; 2900070H08Rik; BOS_4359; calcium binding protein amplified in mutlidrug-resistant cells; CP22; CP-22; H_RG167B05.1; SCN; Sor; Sorcin; Sri; V19
Gene Symbols Sri
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human SR1/Sorcin.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6717
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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