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Invitrogen™ Sortilin Polyclonal Antibody
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Catalog No. PIPA529195
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100 μL
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PIPA529195 100 μL
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Catalog No. PIPA529195 Supplier Invitrogen™ Supplier No. PA529195
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: Mouse brain. Predicted reactivity: Mouse (89%), Rat (90%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Sortilin is required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). It is also required for protein transport from the Golgi apparatus to the endosomes. Sortilin promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also, Sortilin acts as a receptor for neurotensin.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Sortilin
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene Sort1
Gene Accession No. O54861, Q6PHU5, Q99523
Gene Alias 100 kDa NT receptor; 2900053A11Rik; AI852375; Glycoprotein 110; glycoprotein 95; Gp110; Gp95; LDLCQ6; mNTR3; neurotensin receptor 3; NT3; NTR3; Nts3; Ntsr3; Sort1; Sortilin; sortilin 1
Gene Symbols Sort1
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the Extracellular domain of human Sortilin 1. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20661, 6272, 83576
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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