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Invitrogen™ Sortilin Polyclonal Antibody
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Catalog No. PIPA596865
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100 μL
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PIPA596865 100 μL
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Catalog No. PIPA596865 Supplier Invitrogen™ Supplier No. PA596865
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Description

Rabbit Polyclonal Antibody

Positive Samples: A-549, Jurkat; Cellular Location: Cell membrane, Endoplasmic reticulum membrane, Endosome membrane, Extracellular side, Golgi apparatus, Golgi stack membrane, Lysosome membrane, Membrane, Nucleus membrane, Single-pass type I membrane protein Immunogen sequence: GRFLVHRYSV LQQHAEANGV DGVDALDTAS HTNKSGYHD.

Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Sortilin is required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). It is also required for protein transport from the Golgi apparatus to the endosomes. Sortilin promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also, Sortilin acts as a receptor for neurotensin.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Sortilin
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.59 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Sort1
Gene Accession No. O54861, Q6PHU5, Q99523
Gene Alias 100 kDa NT receptor; 2900053A11Rik; AI852375; Glycoprotein 110; glycoprotein 95; Gp110; Gp95; LDLCQ6; mNTR3; neurotensin receptor 3; NT3; NTR3; Nts3; Ntsr3; Sort1; Sortilin; sortilin 1
Gene Symbols Sort1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 785-823 of human SORT1 (NP_0029503).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20661, 6272, 83576
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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