MilliporeSigma™ Sorting Nexin-11, Rabbit, Unlabeled, Polyclonal,

Catalog No.	Quantity	Conjugate
ABC1444MI	100 μL	Unconjugated

Catalog No. ABC1444MI Supplier MilliporeSigma™ Supplier No. ABC1444

Description

Rabbit Polyclonal Antibody

Sorting nexin-11 (UniProt Q91WL6) is encoded by the Snx11 gene (Gene ID 74479) in murine species. Sorting nexins (SNXs) are involved in diverse intracellular endosomal traffickings. Their phox homology (PX) domain binds certain phosphatidylinositols (PIs) and mediates their recruitment to PI-rich vesicles. Most SNXs contain additional recognizable domains and are referred to as SNX PX-BAR or SNX PX-other, while SNX3, SNX10, SNX11, SNX12, SNX22, and SNX24 contain only the PX domain and are referred to as SNX PX. SNX11 is found to contain a novel PXe domain (a.a. 16-132 of human and mouse SNX11) with two additional α-helices next to the conventional PX domain structure composed of three β-strands and three α-helices. F2RL1 (a.k.a. PAR2) is a protease-activated GPCR highly expressed throughout the central and the peripheral nervous system. F2RL1 is reported to translocate from the plasma membrane to nucleus upon stimulation via a microtubule-dependent shuttle machinery that requires sorting nexin 11.

Specifications

• Antigen: Sorting Nexin-11
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: Please refer to lot specific datasheet.
• Conjugate: Unconjugated
• Formulation: Purified rabbit polyclonal antibody in PBS with 0.05% Sodium Azide.
• Gene: Snx11
• Gene Accession No.: Q91WL6
• Host Species: Rabbit
• Immunogen: Linear peptide corresponding to an internal sequence from the C-terminal half of mouse sorting nexin-11.
• Purification Method: Affinity Purified
• Quantity: 100 μL
• Regulatory Status: RUO
• Research Discipline: Apoptosis & Cancer
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_001156861
• Test Specificity: This polyclonal antibody reacts with both human and murine sorting nexin-11. The immunogen sequence is also present in human spliced isoform 2 and rat sorting nexin-11.
• Target Species: Human
• Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.

For Research Use Only. Not for use in diagnostic procedures.