Invitrogen™ SOS1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596239

Catalog No. PIPA596239

Description

Immunogen sequence: PLKSPGVRPS NPRPGTMRHP TPLQQEPRKI SYSRIPESET ESTASAPNSP RTPLTPPPAS GASSTTDVCS VFDSDHSSPF HSSNDTVFIQ VTLPHGPRSA SVSSISLTKG TDEVPVPPPV PPRRRPESAP AESSPSKIMS KHLDSPPAIP PRQPTSKAYS PRYSISDRTS ISDPPESPPL LPPREPVRTP DVFSSSPLHL QPPPLGKKSD HGNAFFPNSP SPFTPPPPQT PSPHGTRRHL PSPPLTQEVD LHSIAGPPVP PRQSTSQHIP KLPPKTYKRE HTHPSMHRDG PPLLENAHSS; Positive Samples: HeLa, Mouse liver, Rat brain, Rat liver.

Son of sevenless (SOS) is a guanine nucleotide exchange factor that activates Ras in response to growth factor stimulation. Sos1, and its closely related Sos2 paralog, are comprised of an N-terminal histone-binding domain, a RacGEF catalytic (DH) domain juxtaposed with a PH domain, a Ras exchanger motif (REM) domain, a RasGEF catalytic domain, and a C-terminal proline-rich region. Sos1 catalyzes the GDP-GTP exchange within the membrane-bound GTPase Ras and thereby switches on a key signaling circuit that involves the activation of MAPK cascade central to cellular proliferation, survival and differentiation. Growth factor stimulation rapidly induces the phosphorylation of Sos on multiple serine and threonine sites. Phosphorylation of residues within the Sos C-terminus by the MAP/ERK kinase disrupts the Grb2-Sos complex.

Specifications

• Antigen: SOS1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SOS1
• Gene Alias: 4430401P03Rik; 9630010N06; AI449023; G GINGF; GF1; GGF1; GINGF; gingival fibromatosis; gingival fibromatosis, hereditary, 1; guanine nucleotide exchange factor; guanine nucleotide releasing factor; HGF; NS4; ras guanine exchange factor; son of sevenless homolog 1; Son of sevenless homolog 1 (Drosophila); son-of-sevenless 1; SOS Ras/Rac guanine nucleotide exchange factor 1; SOS1; SOS-1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20662, 313845, 6654
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.14 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q07889, Q62245
• Gene Symbols: SOS1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1034-1333 of human SOS1 (NP_0056242).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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