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Invitrogen™ SOS1 Polyclonal Antibody
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Catalog No. PIPA596239
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100 μL
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PIPA596239 100 μL
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Catalog No. PIPA596239 Supplier Invitrogen™ Supplier No. PA596239
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: PLKSPGVRPS NPRPGTMRHP TPLQQEPRKI SYSRIPESET ESTASAPNSP RTPLTPPPAS GASSTTDVCS VFDSDHSSPF HSSNDTVFIQ VTLPHGPRSA SVSSISLTKG TDEVPVPPPV PPRRRPESAP AESSPSKIMS KHLDSPPAIP PRQPTSKAYS PRYSISDRTS ISDPPESPPL LPPREPVRTP DVFSSSPLHL QPPPLGKKSD HGNAFFPNSP SPFTPPPPQT PSPHGTRRHL PSPPLTQEVD LHSIAGPPVP PRQSTSQHIP KLPPKTYKRE HTHPSMHRDG PPLLENAHSS; Positive Samples: HeLa, Mouse liver, Rat brain, Rat liver.

Son of sevenless (SOS) is a guanine nucleotide exchange factor that activates Ras in response to growth factor stimulation. Sos1, and its closely related Sos2 paralog, are comprised of an N-terminal histone-binding domain, a RacGEF catalytic (DH) domain juxtaposed with a PH domain, a Ras exchanger motif (REM) domain, a RasGEF catalytic domain, and a C-terminal proline-rich region. Sos1 catalyzes the GDP-GTP exchange within the membrane-bound GTPase Ras and thereby switches on a key signaling circuit that involves the activation of MAPK cascade central to cellular proliferation, survival and differentiation. Growth factor stimulation rapidly induces the phosphorylation of Sos on multiple serine and threonine sites. Phosphorylation of residues within the Sos C-terminus by the MAP/ERK kinase disrupts the Grb2-Sos complex.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SOS1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.14 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene SOS1
Gene Accession No. Q07889, Q62245
Gene Alias 4430401P03Rik; 9630010N06; AI449023; G GINGF; GF1; GGF1; GINGF; gingival fibromatosis; gingival fibromatosis, hereditary, 1; guanine nucleotide exchange factor; guanine nucleotide releasing factor; HGF; NS4; ras guanine exchange factor; son of sevenless homolog 1; Son of sevenless homolog 1 (Drosophila); son-of-sevenless 1; SOS Ras/Rac guanine nucleotide exchange factor 1; SOS1; SOS-1
Gene Symbols SOS1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1034-1333 of human SOS1 (NP_0056242).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20662, 313845, 6654
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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