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Invitrogen™ SOS1 Recombinant Rabbit Monoclonal Antibody (2B2)
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Catalog No. FEMA550137
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100 μL
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FEMA550137 100 μL
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Catalog No. FEMA550137 Supplier Invitrogen™ Supplier No. MA550137
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Description

Rabbit Recombinant Monoclonal Antibody

SOS1 Recombinant Monoclonal Antibody for ELISA, Flow

Son of sevenless (SOS) is a guanine nucleotide exchange factor that activates Ras in response to growth factor stimulation. Sos1, and its closely related Sos2 paralog, are comprised of an N-terminal histone-binding domain, a RacGEF catalytic (DH) domain juxtaposed with a PH domain, a Ras exchanger motif (REM) domain, a RasGEF catalytic domain, and a C-terminal proline-rich region. Sos1 catalyzes the GDP-GTP exchange within the membrane-bound GTPase Ras and thereby switches on a key signaling circuit that involves the activation of MAPK cascade central to cellular proliferation, survival and differentiation. Growth factor stimulation rapidly induces the phosphorylation of Sos on multiple serine and threonine sites. Phosphorylation of residues within the Sos C-terminus by the MAP/ERK kinase disrupts the Grb2-Sos complex.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SOS1
Applications ELISA, Flow Cytometry
Classification Recombinant Monoclonal
Clone 2B2
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
Gene SOS1
Gene Accession No. Q07889
Gene Alias 4430401P03Rik; 9630010N06; AI449023; G GINGF; GF1; GGF1; GINGF; gingival fibromatosis; gingival fibromatosis, hereditary, 1; guanine nucleotide exchange factor; guanine nucleotide releasing factor; HGF; NS4; ras guanine exchange factor; son of sevenless homolog 1; Son of sevenless homolog 1 (Drosophila); son-of-sevenless 1; SOS Ras/Rac guanine nucleotide exchange factor 1; SOS1; SOS-1
Gene Symbols SOS1
Host Species Rabbit
Immunogen A synthesized peptide derived from Human SOS1.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6654
Target Species Human
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG
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