Invitrogen™ SOS1 Recombinant Rabbit Monoclonal Antibody (JE30-06)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA544843

Catalog No. PIMA544843

Description

SOS1 Recombinant Monoclonal Antibody for Western Blot

Son of sevenless (SOS) is a guanine nucleotide exchange factor that activates Ras in response to growth factor stimulation. Sos1, and its closely related Sos2 paralog, are comprised of an N-terminal histone-binding domain, a RacGEF catalytic (DH) domain juxtaposed with a PH domain, a Ras exchanger motif (REM) domain, a RasGEF catalytic domain, and a C-terminal proline-rich region. Sos1 catalyzes the GDP-GTP exchange within the membrane-bound GTPase Ras and thereby switches on a key signaling circuit that involves the activation of MAPK cascade central to cellular proliferation, survival and differentiation. Growth factor stimulation rapidly induces the phosphorylation of Sos on multiple serine and threonine sites. Phosphorylation of residues within the Sos C-terminus by the MAP/ERK kinase disrupts the Grb2-Sos complex.

Specifications

• Antigen: SOS1
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q07889, Q62245
• Gene Symbols: SOS1
• Immunogen: Recombinant protein within human SOS1 aa 1-150/1,333.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Clone: JE30-06
• Conjugate: Unconjugated
• Gene: SOS1
• Gene Alias: 4430401P03Rik; 9630010N06; AI449023; G GINGF; GF1; GGF1; GINGF; gingival fibromatosis; gingival fibromatosis, hereditary, 1; guanine nucleotide exchange factor; guanine nucleotide releasing factor; HGF; NS4; ras guanine exchange factor; son of sevenless homolog 1; Son of sevenless homolog 1 (Drosophila); son-of-sevenless 1; SOS Ras/Rac guanine nucleotide exchange factor 1; SOS1; SOS-1
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 20662, 313845, 6654
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid