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Invitrogen™ SOX1 Polyclonal Antibody
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Catalog No. PIPA5103020
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100 μL
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PIPA5103020 100 μL
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Catalog No. PIPA5103020 Supplier Invitrogen™ Supplier No. PA5103020
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total SOX1.

SOX1, also known as SRY (sex determining region Y)-box 1, is a transcription factor belonging to the SRY-related HMG box family of transcription factors with a HMG box DNA-binding domain. SOX1 works through multiple independent pathways to promote neuronal cell fate determination and differentiation. This nuclear protein acts as a modulator of LINE retroposons promoter activity and is also involved in the development of the central nervous system, mainly neural and lens development. Transcriptional activator SOX1 binds directly to the HES1 promoter and suppresses HES1 transcription, thus attenuating Notch signaling. It also binds to beta-catenin and suppresses beta-catenin-mediated TCF/LEF signaling, thus potentially attenuating the WNT signaling pathway. Expression of SOX1 is seen mostly in embryonic tissues and moderately in brain.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SOX1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene SOX1
Gene Accession No. O00570
Gene Alias BB176347; LOC100912302; sex determining region Y-box 1; Sox1; Sox-1; sox1.S; SRY (sex determining region Y)-box 1; SRY box 1; SRY-box 1; SRY-box 1 S homeolog; SRY-box containing gene 1; SRY-box containing protein; SRY-box transcription factor 1; SRY-related HMG-box gene 1; transcription factor SOX-1; transcription factor SOX-1-like; XELAEV_18015596mg; XlSox1; xSox1
Gene Symbols SOX1
Host Species Rabbit
Immunogen A synthesized peptide derived from human SOX1(Accession O00570), corresponding to amino acid residues H239-G289.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6656
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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