Invitrogen™ SOX1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA595248

Catalog No. PIPA595248

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: Rat Brain Tissue, NIH3T3 whole cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

SOX1, also known as SRY (sex determining region Y)-box 1, is a transcription factor belonging to the SRY-related HMG box family of transcription factors with a HMG box DNA-binding domain. SOX1 works through multiple independent pathways to promote neuronal cell fate determination and differentiation. This nuclear protein acts as a modulator of LINE retroposons promoter activity and is also involved in the development of the central nervous system, mainly neural and lens development. Transcriptional activator SOX1 binds directly to the HES1 promoter and suppresses HES1 transcription, thus attenuating Notch signaling. It also binds to beta-catenin and suppresses beta-catenin-mediated TCF/LEF signaling, thus potentially attenuating the WNT signaling pathway. Expression of SOX1 is seen mostly in embryonic tissues and moderately in brain.

Specifications

• Antigen: SOX1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SOX1
• Gene Alias: BB176347; LOC100912302; sex determining region Y-box 1; Sox1; Sox-1; sox1.S; SRY (sex determining region Y)-box 1; SRY box 1; SRY-box 1; SRY-box 1 S homeolog; SRY-box containing gene 1; SRY-box containing protein; SRY-box transcription factor 1; SRY-related HMG-box gene 1; transcription factor SOX-1; transcription factor SOX-1-like; XELAEV_18015596mg; XlSox1; xSox1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100912302, 20664, 6656
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 5mg BSA and 0.05mg sodium azide
• Gene Accession No.: O00570, P53783
• Gene Symbols: SOX1
• Immunogen: A synthetic peptide corresponding to a sequence in the middle region of Human SOX1 (215-248aa QHPGAGGAHPHAHPAHPHPHHPHAHPHNPQPMHR).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov