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SOX1 Rabbit anti-Human, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 207441AP

Catalog No. 50-173-3060


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Description

Description

SOX1, also known as SRY (sex determining region Y)-box 1, is a transcription factor belonging to the SRY-related HMG box family of transcription factors with a HMG box DNA-binding domain. SOX1 works through multiple independent pathways to promote neuronal cell fate determination and differentiation. This nuclear protein acts as a modulator of LINE retroposons promoter activity and is also involved in the development of the central nervous system, mainly neural and lens development. Transcriptional activator SOX1 binds directly to the HES1 promoter and suppresses HES1 transcription, thus attenuating Notch signaling. It also binds to beta-catenin and suppresses beta-catenin-mediated TCF/LEF signaling, thus potentially attenuating the WNT signaling pathway. Expression of SOX1 is seen mostly in embryonic tissues and moderately in brain.
Specifications

Specifications

SOX1
0.33 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
O00570
SOX1, Transcription factor SOX 1
Rabbit
IgG
150 μL
-20°C
Primary
6656
Western Blot
Unconjugated
SOX1
Liquid
SOX1
Peptide
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Documents
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