Invitrogen™ SOX6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA534616

Catalog No. PIPA534616

Description

PA5-34616 targets SOX6 in ChIP, IHC (F, PFA), IHC (P), and WB applications and shows reactivity with Mouse and Rat samples. The PA5-34616 immunogen is synthetic peptide conjugated to KLH derived from within residues 800 to the C-terminus of Mouse SOX6.

The SOX6 gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors, which are known to play vital roles in the regulation of developmental processes and cell fate determination. SOX6, along with its close relatives SOX5 and SOX13, constitutes the SOXD subfamily, which is involved in the regulation of the development of the central nervous system, skeletal system, and cartilage. It functions by binding to specific DNA sequences and modulating the expression of target genes necessary for these developmental processes. SOX6 has been implicated in various functions, such as promoting cartilage formation by acting in conjunction with SOX9 to drive chondrogenesis. In adult neural stem cells, SOX6 is essential for the activation of radial glial-like cells and the generation of new neurons, emphasizing its role in both embryonic development and adult tissue maintenance. The dysregulation of SOX6 has been associated with developmental disorders and its potential involvement in pathologies like cancer, where it influences cell differentiation and proliferation pathways.

Specifications

• Antigen: SOX6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SOX6
• Gene Alias: AI987981; HSSOX6; SOX6; Sox-6; SOXD; SOX-LZ; SRY (sex determining region Y)-box 6; SRY box 6; SRY-box 6; SRY-box containing gene 6; transcription factor SOX-6
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20679
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunohistochemistry (PFA fixed)
• Concentration: 1.0 mg/mL
• Formulation: PBS with 1% BSA and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P40645
• Gene Symbols: SOX6
• Immunogen: Synthetic peptide conjugated to KLH derived from within residues 800 to the C-terminus of Mouse SOX6.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov