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Invitrogen™ SOX9 Monoclonal Antibody (1B11)
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Catalog No. PIMA517177
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100 μg
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Catalog No. Quantity
PIMA517177 100 μg
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Catalog No. PIMA517177 Supplier Invitrogen™ Supplier No. MA517177
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Description

Mouse Monoclonal Antibody

MA5-17177 targets SOX9 in indirect ELISA, ICC, IF and WB applications and shows reactivity with Human samples. The MA5-17177 immunogen is purified recombinant fragment of human SOX9 expressed in E. Coli. MA5-17177 detects SOX9 which has a predicted molecular weight of approximately 56kDa.

SOX9 has a role in sex determination and differentiation of Sertoli cells. It is involved in chondrogenesis and regulates the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes. Translocation of this gene can cause campomelic dysplasia. SOX9 is involved in the formation of testes from the indifferent fetal gonads. It is a major molecular component of the neuron-glia switch in developing spinal cord. During normal development, SOX9 allows the prostate epithelium to outgrow into the mesenchyme and then provides basal cell support for development and maintenance of the luminal epithelium. These functions of SOX9 are subverted in prostate cancer to support tumor growth and invasion. SOX9 may direct the formation of neural crest precursors and the development of a range of neural crest derivative. It has a transcriptional regulation in melanin production in cells. Northern blot analysis shows its expression on adult testis, adult heart, and fetal brain.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SOX9
Applications ELISA, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 1B11
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene SOX9
Gene Accession No. P48436
Gene Alias 2010306G03Rik; AV220920; CMD1; CMPD1; mKIAA4243; SOX 9; Sox9; SOX-9; Sox9 transcription factor; SRA1; SRXX2; SRXY10; SRY (sex determining region Y)-box 9; SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal); SRY (sex determining region Y)-box9; SRY (sex-determining region Y)-box 9 protein; SRY box 9; SRY-box 9; SRY-Box 9 ; SRY-box containing 9; SRY-box containing gene 9; SRY-box containing protein 9; SRY-box transcription factor 9; SRY-related HMG-box, gene 9; transcription activator Sox9; transcription factor SOX-9
Gene Symbols SOX9
Host Species Mouse
Immunogen Purified recombinant fragment of human SOX9 expressed in E. Coli.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6662
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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