SOX9 Monoclonal Antibody (OTI3G3), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA802392

Catalog No. 50-167-9226

Description

SOX9 has a role in sex determination and differentiation of Sertoli cells. It is involved in chondrogenesis and regulates the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes. Translocation of this gene can cause campomelic dysplasia. SOX9 is involved in the formation of testes from the indifferent fetal gonads. It is a major molecular component of the neuron-glia switch in developing spinal cord. During normal development, SOX9 allows the prostate epithelium to outgrow into the mesenchyme and then provides basal cell support for development and maintece of the luminal epithelium. These functions of SOX9 are subverted in prostate cancer to support tumor growth and invasion. SOX9may direct the formation of neural crest precursors and the development of a range of neural crest derivative. It has a transcriptional regulation in melanin production in cells. Northern blot analysis shows its expression on adult testis, adult heart, and fetal brain.

Specifications

• Antigen: SOX9
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P48436
• Gene Symbols: SOX9
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-205 of human SOX9 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI3G3
• Conjugate: Unconjugated
• Gene: SOX9
• Gene Alias: CMD1, CMPD1, SRA1, SRXX2, SRXY10
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6662
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid