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Invitrogen™ SOX9 Recombinant Rabbit Monoclonal Antibody (5Y4J8)
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Catalog No. PIMA542728
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PIMA542728 100 μL
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Catalog No. PIMA542728 Supplier Invitrogen™ Supplier No. MA542728
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Description

Rabbit Recombinant Monoclonal Antibody

Positive test controls include: HepG2, HeLa. The target is usually found in the following locations: Nucleus. Immunogen sequence: HPDYKYQPRR RKSVKNGQAE AEEATEQTHI SPNAIFKALQ ADSPHSSSGM SEVHSPGEHS GQSQGPPTPP TTPKTDVQPG KADLKREGRP LPEGGRQPPI DFRDVDIGEL SSDVISNIET FDVNEFDQYL PP.

SOX9 has a role in sex determination and differentiation of Sertoli cells. It is involved in chondrogenesis and regulates the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes. Translocation of this gene can cause campomelic dysplasia. SOX9 is involved in the formation of testes from the indifferent fetal gonads. It is a major molecular component of the neuron-glia switch in developing spinal cord. During normal development, SOX9 allows the prostate epithelium to outgrow into the mesenchyme and then provides basal cell support for development and maintenance of the luminal epithelium. These functions of SOX9 are subverted in prostate cancer to support tumor growth and invasion. SOX9 may direct the formation of neural crest precursors and the development of a range of neural crest derivative. It has a transcriptional regulation in melanin production in cells. Northern blot analysis shows its expression on adult testis, adult heart, and fetal brain.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SOX9
Applications ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone 5Y4J8
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene SOX9
Gene Accession No. P48436, Q04887
Gene Alias 2010306G03Rik; AV220920; CMD1; CMPD1; mKIAA4243; SOX 9; Sox9; SOX-9; Sox9 transcription factor; SRA1; SRXX2; SRXY10; SRY (sex determining region Y)-box 9; SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal); SRY (sex determining region Y)-box9; SRY (sex-determining region Y)-box 9 protein; SRY box 9; SRY-box 9; SRY-Box 9 ; SRY-box containing 9; SRY-box containing gene 9; SRY-box containing protein 9; SRY-box transcription factor 9; SRY-related HMG-box, gene 9; transcription activator Sox9; transcription factor SOX-9
Gene Symbols SOX9
Host Species Rabbit
Immunogen Recombinant protein (or fragment).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 140586, 20682, 6662
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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