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Tocris Bioscience™ SP 100030

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Quantity:
10 mg
50 mg
Description
SP 100030 is a potent dual inhibitor of NF-κB and AP-1 transcriptional activity (IC50 = 50 nM). Blocks production of IL-2, IL-8 and TNF-α from Jurkat T cells. Inhibits cytokine production selectively in T cells; exhibits minimal inhibition of cytokine production in other cell types. Decreases arthritic severity in a mouse model of collagen-induced arthritis. Also ameliorates muscle wasting in a rat model of cancer cachexia.
Specifications
Specifications
Chemical Name or Material | N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide |
CAS | 154563-54-9 |
Quantity | 50 mg |
Target | NFkB/IkB Inhibitors |
Molecular Formula | C14H5ClF9N3O |
Formula Weight | 437.65 |
Purity | >99% |
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