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  5. Tocris Bioscience™ SP 100030

Tocris Bioscience™ SP 100030
GREENER_CHOICE

Catalog No. 530950
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

NF-κB and AP-1 dual inhibitor

SP 100030 is a potent dual inhibitor of NF-κB and AP-1 transcriptional activity (IC50 = 50 nM). Blocks production of IL-2, IL-8 and TNF-α from Jurkat T cells. Inhibits cytokine production selectively in T cells; exhibits minimal inhibition of cytokine production in other cell types. Decreases arthritic severity in a mouse model of collagen-induced arthritis. Also ameliorates muscle wasting in a rat model of cancer cachexia.

Specifications

Chemical Name or Material N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide
CAS 154563-54-9
Quantity 50 mg
Target NFkB/IkB Inhibitors
Molecular Formula C14H5ClF9N3O
Formula Weight 437.65
Purity >99%
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