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  5. Tocris Bioscience™ SP 141

Tocris Bioscience™ SP 141
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Catalog No. 533210
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Catalog No. Quantity
53-321-0 10 mg
53-325-0 50 mg
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Catalog No. 53-321-0 Supplier Tocris Bioscience™ Supplier No. 5332/10
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Description

High affinity MDM2 inhibitor

SP 141 is a high affinity MDM2 inhibitor (Ki = 28 nM); directly binds MDM2. SP 141 inhibits MDM2 expression and induces MDM2 autoubiquitination and proteasomal degradation. SP 141 attenuates growth of breast cancer xenograft tumors. SP 141 impairs liposarcoma growth in vitro and in human xenograft models. SP 141 is cell permeable.

Specifications

Quantity 10 mg
Product Type SP 141
Purity >98%
Molecular Weight (g/mol) 324.38

For Research Use Only

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