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Invitrogen™ SP110 Monoclonal Antibody (OTI4C1)
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Catalog No. PIMA526924
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100 μL
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PIMA526924 100 μL
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Catalog No. PIMA526924 Supplier Invitrogen™ Supplier No. MA526924
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Description

Mouse Monoclonal Antibody

SP110 Monoclonal Antibody for Western Blot, IHC (P)

Susceptibility to tuberculosis (TB) in mice has recently been attributed to the IPR1 gene. IPR1 is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. SP110 is the closest homolog of the IPR1 protein in humans. The IPR1/Sp110 gene product might play a role in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death, and pathogenesis. IPR1/Sp110 is up-regulated after infection with M. tuberculosis and required by Anaplasma phagocytophilum for infection of human promyelocytic cells. Defects in Sp110 are a cause of severely impaired resistance to infection by M. tuberculosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SP110
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI4C1
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene SP110
Gene Accession No. Q9HB58
Gene Alias 5031415C07Rik; 52kDa; 5830484A20Rik; ENSMUSG00000075603; IFI41; Ifi75; interferon-induced protein 41, 30kD; interferon-induced protein 41/75; interferon-induced protein 75, 52kD; intracellular pathogen resistance 1; intracellular pathogen resistance protein 1; Ipr1; phosphoprotein 41; phosphoprotein 75; SP110; Sp110 nuclear body protein; speckled 110 kDa; Transcriptional coactivator Sp110; VODI
Gene Symbols SP110
Host Species Mouse
Immunogen Human recombinant protein fragment corresponding to amino acids 232-521 of SP110 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3431
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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