Invitrogen™ SPACA3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA570740

Catalog No. PIPA570740

Description

This target displays homology in the following species: Cow: 86%; Dog: 86%; Goat: 86%; Horse: 100%; Human: 100%; Mouse: 79%; Pig: 93%; Rabbit: 86%; Rat: 92%; Sheep: 86%.

SPACA3 (sperm acrosome associated 3), also known as sperm lysozyme-like protein 1, lysozyme-like protein 3, lysozyme-like acrosomal sperm-specific secretory protein ALLP-17, cancer/testis antigen 54 (CT54), LYC3, SPRASA or LYZL3, is a 215 amino acid protein that participates in the fusion and adhesion of sperm and egg plasma membrane during fertilization. Identified as a novel cancer/testis antigen in hematologic malignancies, SPACA3 has the ability to elicit B-cell immune responses in patients with cancer and is considered a potential target for immunotherapy. A member of the glycosyl hydrolase 22 family which is expressed in testis, placenta and epididymis, SPACA3 exists as two alternatively spliced isoforms; SPACA3 isoform 1 is a single-pass type II membrane protein of the sperm acrosome whereas SPACA3 isoform 2 is a secreted protein. Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.

Specifications

• Antigen: SPACA3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SPACA3
• Gene Alias: 1700025M08Rik; acrosomal sperm protein; ALLP17; Cancer/testis antigen 54; CT54; LYC3; lysozyme C; lysozyme-like acrosomal sperm-specific secretory protein ALLP-17; Lysozyme-like protein 3; lysozyme-like sperm-specific secretory protein ALLP17; LYZC; Lyzl3; mSLLP1; SLLP1; Spaca3; sperm acrosome associated 3; sperm acrosome membrane-associated protein 3; Sperm acrosome membrane-associated protein 3, membrane form; Sperm acrosome membrane-associated protein 3, processed form; sperm c-type lysozyme-like protein; sperm lysozyme like protein 1; sperm lysozyme-like protein 1; sperm lysozyme-like protein 1 precusor; sperm lyzozyme-like acrosomal protein 1; Sperm protein reactive with antisperm antibodies; Sperm protein reactive with ASA; SPRASA; UNQ424/PRO862
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 75622
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q9D9X8
• Gene Symbols: SPACA3
• Immunogen: synthetic peptide directed towards the C-terminal region of mouse SPACA3.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG