SPACA3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-173-3275	Proteintech Group Inc 211371AP150UL	150 μL

Description

SPACA3 (sperm acrosome associated 3), also known as sperm lysozyme-like protein 1, lysozyme-like protein 3, lysozyme-like acrosomal sperm-specific secretory protein ALLP-17, cancer/testis antigen 54 (CT54), LYC3, SPRASA or LYZL3, is a 215 amino acid protein that participates in the fusion and adhesion of sperm and egg plasma membrane during fertilization. Identified as a novel cancer/testis antigen in hematologic maligcies, SPACA3 has the ability to elicit B-cell immune responses in patients with cancer and is considered a potential target for immunotherapy. A member of the glycosyl hydrolase 22 family which is expressed in testis, placenta and epididymis, SPACA3 exists as two alternatively spliced isoforms; SPACA3 isoform 1 is a single-pass type II membrane protein of the sperm acrosome whereas SPACA3 isoform 2 is a secreted protein. Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.

Specifications

• Antigen: SPACA3
• Applications: Immunocytochemistry, Immunofluorescence, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: Q8IXA5, Q9D9X8
• Gene ID (Entrez): 124912, 287557, 75622
• Immunogen: SPACA3 Fusion Protein Ag15589
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: SPACA3

• Concentration: 0.41 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: 1700025M08Rik, ALLP17, Cancer/testis antigen 54, CT54, LYC3, Lysozyme like protein 3, LYZL3, SLLP1, SPACA3, sperm acrosome associated 3, Sperm lysozyme like protein 1, SPRASA
• Gene Symbols: Spaca3
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody