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Invitrogen™ SPAG1 Polyclonal Antibody
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Catalog No. PIPA545738
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100 μL
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Catalog No. Quantity
PIPA545738 100 μL
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Catalog No. PIPA545738 Supplier Invitrogen™ Supplier No. PA545738
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Description

Rabbit Polyclonal Antibody

Peptide sequence: LHVGKEKYSK RPTKKKTPRD YAEWDKFDVE KECLKIDEDY KEKTVIDKSH Sequence homology: Dog: 85%; Human: 100%.

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SPAG1
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene SPAG1
Gene Accession No. Q07617
Gene Alias CILD28; CT140; epididymis secretory protein Li 268; HEL-S-268; HSD-3.8; Infertility-related sperm protein Spag-1; SP75; SPAG1; sperm associated antigen 1; sperm-associated antigen 1; sperm-associated antigen 1; LOW QUALITY PROTEIN: sperm-associated antigen 1; tetratricopeptide repeat-containing protein; TPIS; TPR-containing protein involved in spermatogenesis
Gene Symbols SPAG1
Host Species Rabbit
Immunogen Synthetic peptide directed towards the N-terminal of human SPAG1 (aa 138-187).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6674
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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