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Invitrogen™ SPAG5 Monoclonal Antibody (OTI6G2)
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Catalog No. PIMA527302
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Quantity:
100 μL
Catalog No. Quantity
PIMA527302 100 μL
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Catalog No. PIMA527302

Supplier: Invitrogen™ MA527302

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Description

Mouse Monoclonal Antibody

SPAG5 Monoclonal Antibody for Western Blot

SPAG5 (sperm associated antigen 5), also known as MAP126, hMAP126, DEEPEST or Astrin, is a 1,193 amino acid protein that is expressed at high levels in testis and at lower levels in liver, placenta, pancreas, colon and thymus. Localized specifically to spindle poles during prophase and throughout the spindle during metaphase and anaphase, SPAG5 is essential for proper spindle formation and is thought to be involved in the dynamic and functional regulation of mitotic spindles. Additionally, SPAG5 plays a role in sister chromatid cohesion and subsequent chromatid separation and, via its association with chromatids, is an important regulator of chromosome integrity. SPAG5 has a long stalk and a globular head domain through which if forms a homodimer that is characterized by aster-like structures. Upon DNA damage, SPAG5 may be phosphorylated by ATR or ATM.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SPAG5
Applications Western Blot
Classification Monoclonal
Clone OTI6G2
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene SPAG5
Gene Accession No. Q96R06
Gene Alias AI874642; Astrin; D11Bhm180e; Deepest; hMAP126; MAP126; Mastrin; microtubule-associated protein; mitotic spindle associated protein p126; mitotic spindle coiled-coil related protein; mitotic spindle-associated protein p126; S17; Spag5; sperm associated antigen 5; sperm-associated antigen 5
Gene Symbols SPAG5
Host Species Mouse
Immunogen Human recombinant protein fragment corresponding to amino acids 1-297 of SPAG5 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10615
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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