Invitrogen™ SPAG5 Monoclonal Antibody (OTI6G2)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA527302

Catalog No. PIMA527302

Description

SPAG5 Monoclonal Antibody for Western Blot

SPAG5 (sperm associated antigen 5), also known as MAP126, hMAP126, DEEPEST or Astrin, is a 1,193 amino acid protein that is expressed at high levels in testis and at lower levels in liver, placenta, pancreas, colon and thymus. Localized specifically to spindle poles during prophase and throughout the spindle during metaphase and anaphase, SPAG5 is essential for proper spindle formation and is thought to be involved in the dynamic and functional regulation of mitotic spindles. Additionally, SPAG5 plays a role in sister chromatid cohesion and subsequent chromatid separation and, via its association with chromatids, is an important regulator of chromosome integrity. SPAG5 has a long stalk and a globular head domain through which if forms a homodimer that is characterized by aster-like structures. Upon DNA damage, SPAG5 may be phosphorylated by ATR or ATM.

Specifications

• Antigen: SPAG5
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q96R06
• Gene Symbols: SPAG5
• Immunogen: Human recombinant protein fragment corresponding to amino acids 1-297 of SPAG5 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI6G2
• Conjugate: Unconjugated
• Gene: SPAG5
• Gene Alias: AI874642; Astrin; D11Bhm180e; Deepest; hMAP126; MAP126; Mastrin; microtubule-associated protein; mitotic spindle associated protein p126; mitotic spindle coiled-coil related protein; mitotic spindle-associated protein p126; S17; Spag5; sperm associated antigen 5; sperm-associated antigen 5
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10615
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid