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Invitrogen™ SPAG6 Polyclonal Antibody
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Catalog No. PIPA558389
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100 μL
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PIPA558389 100 μL
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Catalog No. PIPA558389 Supplier Invitrogen™ Supplier No. PA558389
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: AVPLLVLCIQ EPEIALKRIA ASALSDIAKH SPELAQTVVD AGAVAHLAQM ILNPDAKLKH QILSALSQVS KHSVDLAEMV VEA Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 92%.

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SPAG6
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SPAG6
Gene Accession No. O75602
Gene Alias axoneme central apparatus protein; CT141; PF16; protein PF16 homolog; Repro-SA-1; RGD1310892; SPAG6; Spag6l; sperm associated antigen 6; sperm associated antigen 6 like; sperm flagellar protein; Sperm-associated antigen 6; testicular tissue protein Li 176
Gene Symbols SPAG6
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SPAG6. Recombinant protein control fragment (Product #RP-97008).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9576
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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