Invitrogen™ SPAG6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA558389

Catalog No. PIPA558389

Description

Immunogen sequence: AVPLLVLCIQ EPEIALKRIA ASALSDIAKH SPELAQTVVD AGAVAHLAQM ILNPDAKLKH QILSALSQVS KHSVDLAEMV VEA Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 92%.

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.

Specifications

• Antigen: SPAG6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SPAG6
• Gene Alias: axoneme central apparatus protein; CT141; PF16; protein PF16 homolog; Repro-SA-1; RGD1310892; SPAG6; Spag6l; sperm associated antigen 6; sperm associated antigen 6 like; sperm flagellar protein; Sperm-associated antigen 6; testicular tissue protein Li 176
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9576
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.4 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O75602
• Gene Symbols: SPAG6
• Immunogen: Recombinant protein corresponding to Human SPAG6. Recombinant protein control fragment (Product #RP-97008).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG