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SPAG6 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501982110
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100 μL
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50-198-2110 100 μL
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Catalog No. 50-198-2110 Supplier Bioss Supplier No. BS12291R
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Rabbit Polyclonal Antibody

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.

Specifications

Antigen SPAG6
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene SPAG6
Gene Accession No. O75602
Gene Alias axoneme central apparatus protein; CT141; PF16; Protein PF16 homolog; Repro-SA-1; RGD1310892; SPAG6; Spag6l; sperm associated antigen 6; sperm associated antigen 6 like; Sperm flagellar protein; Sperm-associated antigen 6; testicular tissue protein Li 176
Gene Symbols SPAG6
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human SPAG6.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9576
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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