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SPAK Polyclonal Antibody, Bethyl Laboratories

Catalog No. 501572539
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50-157-2539 100 μL
50-157-2540 10 μL
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Catalog No. 50-157-2539 Supplier Bethyl Laboratories, Inc Supplier No. IHC00686
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Gorilla, Chimpanzee and Northern white-cheeked gibbon

Programmed cell death 5 (PDCD5), a human apoptosis-related protein, is thought to play an early and universal role in apoptosis. PDCD5 is widely expressed and is upregulated in cells undergoing apoptosis, where it translocates rapidly from the cytoplasm to the nucleus. PDCD5 has a compact core structure of low flexibility with two mobile alpha-helices at N-terminal and a flexible unstructured C-terminal region. The charged residues are crucial for the ability of apoptosis-promoting and cell translocation of the protein. PDCD5 can facilitate apoptosis and enhance TAJ/TROY-induced paraptosis-like cell death. PDCD5 may play a dual role in the Tip60 pathway. It interacts with Tip60 and functions as a Tip60 co-activator to promote apoptosis. The nucleotide polymorphisms in the 5′-upstream region ofPDCD5 affect promoter activity and the susceptibility of a Chinese population to develop chronic myelogenous leukemia and may represent a novel tumor suppressor gene influencing lung cancer.

Specifications

Antigen SPAK
Applications Immunohistochemistry
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene STK39
Gene Accession No. Q9UEW8
Gene Alias STE20/SPS1-related proline-alanine-rich protein kinase; Ste-20-related kinase; Serine/threonine-protein kinase 39; DCHT; STK39; SPAK;
Gene Symbols STK39
Host Species Rabbit
Immunogen Between 425 and 450
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27347
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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