Invitrogen™ SPAM1 Polyclonal Antibody

Catalog No.	Quantity
PIPA5102582	100 μL

Catalog No. PIPA5102582 Supplier Invitrogen™ Supplier No. PA5102582

Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total SPAM1. On mouse sample, this antibody also recognizes HYAL5 and HYAL2.

Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: SPAM1
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene: SPAM1
• Gene Accession No.: P38567, P48794
• Gene Alias: AV039194; epididymis secretory sperm binding protein Li 96n; HEL-S-96n; HYA1; HYAL1; HYAL3; HYAL5; hyal-PH20; Hyaluronidase PH-20; hyaluronoglucosaminidase PH-20; MGC26532; PH20; Ph-20; PH-20 hyaluronidase; SPAG15; Spam; SPAM1; Sperm adhesion molecule 1; sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding); sperm surface antigen 2B1; Sperm surface protein PH-20
• Gene Symbols: SPAM1
• Host Species: Rabbit
• Immunogen: A synthesized peptide derived from human SPAM1(Accession P38567), corresponding to amino acid residues L206-S256.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 20690, 6677
• Target Species: Human, Mouse
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

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