Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. PIPA545549

Invitrogen™ SPAM1 Polyclonal Antibody
GREENER_CHOICE

Catalog No. PIPA545549
Change view
Click to view available options
Quantity:
100 μL
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
PIPA545549 100 μL
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. PIPA545549 Supplier Invitrogen™ Supplier No. PA545549
Add to Cart
Add to Cart

Description

Rabbit Polyclonal Antibody

Peptide sequence: CYSTLSCKEK ADVKDTDAVD VCIADGVCID AFLKPPMETE EPQIFYNASP Sequence homology: Human: 100%.

Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SPAM1
Applications Western Blot, Surface Plasmon Resonance
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene SPAM1
Gene Accession No. P38567
Gene Alias AV039194; epididymis secretory sperm binding protein Li 96n; HEL-S-96n; HYA1; HYAL1; HYAL3; HYAL5; hyal-PH20; Hyaluronidase PH-20; hyaluronoglucosaminidase PH-20; MGC26532; PH20; Ph-20; PH-20 hyaluronidase; SPAG15; Spam; SPAM1; Sperm adhesion molecule 1; sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding); sperm surface antigen 2B1; Sperm surface protein PH-20
Gene Symbols SPAM1
Host Species Rabbit
Immunogen Synthetic peptide directed towards the C-terminal of human SPAM1 (aa 437-486).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6677
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
Show More Show Less

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.