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Invitrogen™ SPAM1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5102582

Catalog No. PIPA5102582


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Description

Description

Antibody detects endogenous levels of total SPAM1. On mouse sample, this antibody also recognizes HYAL5 and HYAL2.

Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

SPAM1
Polyclonal
Unconjugated
SPAM1
AV039194; epididymis secretory sperm binding protein Li 96n; HEL-S-96n; HYA1; HYAL1; HYAL3; HYAL5; hyal-PH20; Hyaluronidase PH-20; hyaluronoglucosaminidase PH-20; MGC26532; PH20; Ph-20; PH-20 hyaluronidase; SPAG15; Spam; SPAM1; Sperm adhesion molecule 1; sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding); sperm surface antigen 2B1; Sperm surface protein PH-20
Rabbit
Affinity Chromatography
RUO
20690, 6677
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
P38567, P48794
SPAM1
A synthesized peptide derived from human SPAM1(Accession P38567), corresponding to amino acid residues L206-S256.
100 μL
Primary
Human, Mouse
Antibody
IgG
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