SPANXRabbit anti-Human, Polyclonal, Rockland™

Catalog No.	Quantity
50-199-1859	100 μg

Catalog No. 50-199-1859 Supplier Rockland Immunochemicals Supplier No. 600401916

Description

Rabbit Polyclonal Antibody

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. This affinity-purified antibody is directed against human SPANX proteins. The immunogen sequence is present within SPANX-A, SPANX-B, SPANX-C, SPANX-D and SPANX-N, but not present within SPANX-E. A BLAST analysis was used to suggest cross reactivity with SPANX proteins from gorilla and chimpanzee. Reactivity against homologues from other sources is not known.

Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family, which is located in a gene cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a protein that localizes to the nucleus and is expressed in highly metastatic cell lines, making the protein a potential diagnostic and prognostic marker. The protein belongs to a family of cancer/testis antigens and represents a potential target for cancer immunotherapy.

Specifications

• Antigen: SPANX
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
• Gene: SPANXC
• Gene Accession No.: Q9NY87
• Gene Alias: C; Cancer/testis antigen 11.3; cancer/testis antigen family 11, member 3; Cancer/testis-associated protein CTp11; cancer/testis-associated protein of 11 kD; cancer-testis-associated protein CTp11; CT11.3; CTp11; Nuclear-associated protein SPAN-Xc; SPANX family member C; SPANX family, member C; SPANXC; SPANX-C; SPAN-Xc protein; Sperm protein associated with the nucleus on the X chromosome C; sperm protein associated with the nucleus, X chromosome, family member C
• Gene Symbols: SPANXC
• Host Species: Rabbit
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 64663
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid