Invitrogen™ Spastin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA597226

Catalog No. PIPA597226

Description

Immunogen sequence: HKQAFEYISI ALRIDEDEKA GQKEQAVEWY KKGIEELEKG IAVIVTGQGE QCERARRLQA KMMTNLVMAK DRLQLLEKMQ PVLPFSKSQT DVYNDSTNLA CRNGHLQSES GAVPKRKDPL THTSNSLPRS KTVMKTGSAG LSGHHRAPSY SGLSMVSGVK QGSGPAPTTH KGTPKTNRTN KPSTPTTATR KKKDLKNFRN VDSNLA; Positive Samples: Mouse heart; Cellular Location: Cytoplasm, Endoplasmic reticulum, Endosome, Membrane, Nucleus, Single-pass membrane protein, centrosome, cytoskeleton, microtubule organizing center, perinuclear region, spindle.

This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequences have not been determined. Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4.

Specifications

• Antigen: Spastin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SPAST
• Gene Alias: ADPSP; ATPase; fidgetin-like 1; FSP2; HAMAP-Rule:MF_03021}; hypothetical protein zgc:85952; Kiaa1083; KIAA183; LOW QUALITY PROTEIN: spastin; mKIAA1083; si:ch73-233a22.3; SPAST; spastic paraplegia 4 (autosomal dominant; spastic paraplegia 4 (autosomal dominant; spastin); spastic paraplegia 4 homolog; spastic paraplegia 4 protein; Spastin; spastin {ECO:0000255; SPG4; zgc:85952
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6683
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 2.03 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q9UBP0
• Gene Symbols: SPAST
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 120-325 of human SPAST (NP_0557612).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG