Invitrogen™ SPATA13 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA559096

Catalog No. PIPA559096

Description

Immunogen sequence: ALRPAEWGTL DGSDLEDTDD AFQRSTHRSR SLRRAYGLGR ICLLDAPQNH ATPTIATGQV PAVCEILVRD PENNSMGYRR SKSTDNLAFL KKSSFKRKST SNLADLRTAH Highest antigen sequence identity to the following orthologs: Mouse - 54%, Rat - 54%.

Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. [UniProt].

Specifications

• Antigen: SPATA13
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Spata13
• Gene Alias: adenomatous polyposis coli stimulated exchange factor 2; APC-stimulated guanine nucleotide exchange factor 2; ARHGEF29; ASEF2; C79050; ESTM11; mFLJ00298; Spata13; spermatogenesis associated 13; spermatogenesis-associated protein 13; spt13; X83327
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 221178
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96N96
• Gene Symbols: Spata13
• Immunogen: Recombinant protein corresponding to Human SPATA13. Recombinant protein control fragment (Product #RP-98018).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG