Invitrogen™ SPATA13 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5114343

Catalog No. PIPA5114343

Description

SPATA13 Polyclonal Antibody for Western Blot, IHC (P), Flow

Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. [UniProt].

Specifications

• Antigen: SPATA13
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Spata13
• Gene Alias: adenomatous polyposis coli stimulated exchange factor 2; APC-stimulated guanine nucleotide exchange factor 2; ARHGEF29; ASEF2; C79050; ESTM11; mFLJ00298; Spata13; spermatogenesis associated 13; spermatogenesis-associated protein 13; spt13; X83327
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 219140, 221178, 305938
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q5DU57, Q96N96
• Gene Symbols: Spata13
• Immunogen: Recombinant protein within Human SPATA13 aa 423-572.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov