SPDEF Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 114671AP150UL

Catalog No. 50-172-7185

Description

PDEF (prostate-derived Ets factor) is a 37.5- kDa protein that acts as an androgen-independent transcriptional activator for the PSA (prostate specific antigen) promoter. It also interacts directly with the DNA binding domain of androgen receptor and enhances androgen-mediated activation of the PSA promoter. PDEF was shown to have transcript levels 192-fold higher in the peripheral blood of some breast cancer patients in comparison with normal individuals. PDEF mRNA is also frequently over-expressed in human breast tumors as well as in human ovarian tumors. In ovarian tumors, PDEF expression seems to down-modulate maligt potential, and thus provides a rationale to screen for drugs that induce PDEF expression in epithelial ovarian tumors.

Specifications

• Antigen: SPDEF
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SPDEF
• Gene Alias: PDEF, Prostate derived Ets factor, Prostate specific Ets, PSE, RP11 375E1__A.3, SPDEF
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 25803, 30051, 689210
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.31 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: O95238, Q9WTP3
• Gene Symbols: SPDEF
• Immunogen: SPDEF Fusion Protein Ag2020
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG