Invitrogen™ SPDL1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA561667

Catalog No. PIPA561667

Description

Immunogen sequence: LQIATLLQMK GSQTEFEQQE RLLAMLEQKN GEIKHLLGEI RNLEKFKNLY DSMESKPSVD SGTLEDNTYY TDLLQMKLDN LNKEIESTKG ELS Highest antigen sequence identity to the following orthologs: Mouse - 77%, Rat - 79%.

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridizations indicate that this lectin is specifically expressed in keratinocytes. It is expressed at all stages of epidermal differentiation (i.e., in basal and suprabasal layers). The protein was found mainly in stratified squamous epithelium. It is moderately repressed by retinoic acid. The antigen localized to basal keratinocytes, although it was also found at lower levels in the suprabasal layers, where it concentrated to areas of cell-to-cell contact. The cellular localization and its striking down-regulation in cultured keratinocytes imply a role in cell-cell and/or cell-matrix interactions necessary for normal growth control.

Specifications

• Antigen: SPDL1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SPDL1
• Gene Alias: 1700018I02Rik; 2600001J17Rik; 2810049B11Rik; AA409762; arsenite-related gene 1 protein; Ccdc99; coiled-coil domain containing 99; coiled-coil domain-containing protein 99; coiled-coil domain-containing protein 99 {ECO:0000255; HAMAP-Rule:MF_03041}; hSpindly; protein Spindly; RGD1306908; Rhabdomyosarcoma antigen MU-RMS-40.4A; rrhabdomyosarcoma antigen protein MU-RMS-40.4A; SPDL1; Spindle apparatus coiled-coil domain-containing protein 1; spindle apparatus coiled-coil domain-containing protein 1 {ECO:0000255; spindle apparatus coiled-coil protein 1; spindly homolog
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54908
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96EA4
• Gene Symbols: SPDL1
• Immunogen: Recombinant protein corresponding to Human SPDL1. Recombinant protein control fragment (Product #RP-100099).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG