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Invitrogen™ Spectrin alpha-1 Polyclonal Antibody
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Catalog No. PIPA5114843
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100 μL
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PIPA5114843 100 μL
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Catalog No. PIPA5114843 Supplier Invitrogen™ Supplier No. PA5114843
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total alpha 1 Spectrin.

Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. [provided by RefSeq, Jul 2008].
TRUSTED_SUSTAINABILITY

Specifications

Antigen Spectrin alpha-1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene SPTA1
Gene Accession No. P02549, P08032
Gene Alias 2610027H02Rik; A2a; AF093576; a--fodrin; AI451697; alpha II spectrin; alpha-fodrin; alpha-I spectrin; alpha-II spectrin; alpha-spectrin 1, erythroid; alpha-spectrin 2; alpha-spectrin 2, brain; brain alpha-spectrin; EIEE5; EL2; elliptocytosis 2; erythroid alpha-spectrin; erythroid spectrin alpha; fodrin alpha chain; ha; hemolytic anemia; HPP; HS3; ihj; inhibitory protein factor; IPF; mutant alpha spectrin; NEAS; neuroscience mutagenesis facility, 4; nmf4; noerythroid alpha-spectrin 2; nonerythroid alpha-spectrin 2; spectrin alpha 1; spectrin alpha chain, brain; spectrin alpha chain, erythrocyte; spectrin alpha chain, erythrocytic 1; Spectrin alpha chain, non-erythrocytic 1; spectrin alpha, erythrocytic 1; spectrin alpha, non-erythrocytic 1; spectrin, alpha, erythrocytic 1; spectrin, alpha, erythrocytic 1 (elliptocytosis 2); spectrin, alpha, non-erythrocytic 1; spectrin, non-erythroid alpha chain; spectrin, non-erythroid alpha subunit; sph; SPH3; spherocytosis; Spna1; Spna-1; Spna2; Spna-2; SPTA; Spta1; SPTA2; SPTAN1
Gene Symbols SPTA1
Host Species Rabbit
Immunogen A synthesized peptide derived from human SPTA1(Accession P02549), corresponding to amino acid residues M2376-N2419.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20739, 289257, 6708
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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