Invitrogen™ Spectrin alpha-1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA582997

Catalog No. PIPA582997

Description

Immunogen sequence: HQGIVPAVYV RRLAHDEFPM LPQRRREEPG NITQRQEQIE NQYRSLLDRA EERRRRLLQR YNEFLLAYEA GDMLEWIQEK KAENTGVEL.

Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. [provided by RefSeq, Jul 2008].

Specifications

• Antigen: Spectrin alpha-1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SPTA1
• Gene Alias: 2610027H02Rik; A2a; AF093576; a--fodrin; AI451697; alpha II spectrin; alpha-fodrin; alpha-I spectrin; alpha-II spectrin; alpha-spectrin 1, erythroid; alpha-spectrin 2; alpha-spectrin 2, brain; brain alpha-spectrin; EIEE5; EL2; elliptocytosis 2; erythroid alpha-spectrin; erythroid spectrin alpha; fodrin alpha chain; ha; hemolytic anemia; HPP; HS3; ihj; inhibitory protein factor; IPF; mutant alpha spectrin; NEAS; neuroscience mutagenesis facility, 4; nmf4; noerythroid alpha-spectrin 2; nonerythroid alpha-spectrin 2; spectrin alpha 1; spectrin alpha chain, brain; spectrin alpha chain, erythrocyte; spectrin alpha chain, erythrocytic 1; Spectrin alpha chain, non-erythrocytic 1; spectrin alpha, erythrocytic 1; spectrin alpha, non-erythrocytic 1; spectrin, alpha, erythrocytic 1; spectrin, alpha, erythrocytic 1 (elliptocytosis 2); spectrin, alpha, non-erythrocytic 1; spectrin, non-erythroid alpha chain; spectrin, non-erythroid alpha subunit; sph; SPH3; spherocytosis; Spna1; Spna-1; Spna2; Spna-2; SPTA; Spta1; SPTA2; SPTAN1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6708
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P02549
• Gene Symbols: SPTA1
• Immunogen: Recombinant protein corresponding to Human SPTA1. Recombinant protein control fragment (Product #RP-94435).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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