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Invitrogen™ Spectrin beta-3 Polyclonal Antibody
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Catalog No. PIPA560406
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100 μL
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PIPA560406 100 μL
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Catalog No. PIPA560406 Supplier Invitrogen™ Supplier No. PA560406
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RLWRFLWEVG EAEAWVREQQ HLLASADTGR DLTGALRLLN KHTALRGEMS GRLGPLKLTL EQGQQLVAEG HPGASQASA Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.

Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Spectrin beta-3
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Sptbn2
Gene Accession No. O15020
Gene Alias beta SpIII sigma 1; beta-III spectrin; beta-spectrin 3; glutamate transporter EAAT4-associated protein 41; GTRAP41; KIAA0302; mKIAA0302; SCA5; SCAR14; Spectrin Beta; spectrin beta 3; spectrin beta chain, brain 2; spectrin beta chain, non-erythrocytic 2; spectrin beta III sigma 2; spectrin beta, non-erythrocytic 2; spectrin, beta, non-erythrocytic 2; spectrin, non-erythroid beta chain 2; spectrin-like protein GTRAP41; spinocerebellar ataxia 5 protein; Spnb3; SPNB-3; SPTBN2
Gene Symbols Sptbn2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human Spectrin beta-3. Recombinant protein control fragment (Product #RP-103863).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6712
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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