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Invitrogen™ Spectrin beta-3 Polyclonal Antibody
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Catalog No. PA146007
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100 μL
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PA146007 100 μL
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Catalog No. PA146007 Supplier Invitrogen™ Supplier No. PA146007
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Description

Rabbit Polyclonal Antibody

Suggested positive control: Hela whole cell extract.

Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Spectrin beta-3
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Sptbn2
Gene Accession No. O15020
Gene Alias beta SpIII sigma 1; beta-III spectrin; beta-spectrin 3; glutamate transporter EAAT4-associated protein 41; GTRAP41; KIAA0302; mKIAA0302; SCA5; SCAR14; Spectrin Beta; spectrin beta 3; spectrin beta chain, brain 2; spectrin beta chain, non-erythrocytic 2; spectrin beta III sigma 2; spectrin beta, non-erythrocytic 2; spectrin, beta, non-erythrocytic 2; spectrin, non-erythroid beta chain 2; spectrin-like protein GTRAP41; spinocerebellar ataxia 5 protein; Spnb3; SPNB-3; SPTBN2
Gene Symbols Sptbn2
Host Species Rabbit
Immunogen C-terminal region between residue 2340 and 2390 of Spectrin beta 3.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20743, 6712
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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