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Invitrogen™ Spectrin beta-4 Monoclonal Antibody (N393/2), PE
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Catalog No. PIMA545724
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100 μg
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PIMA545724 100 μg
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Catalog No. PIMA545724 Supplier Invitrogen™ Supplier No. MA545724
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Description

Mouse Monoclonal Antibody

A 1:100 dilution of MA5-45724 was sufficient for detection of Beta 4 Spectrin in 20 μg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately >200kDa. Does not cross react with other Beta-spectrins This antibody was formerly sold as clone S393-2.

Spectrin is the major constituent of the cytoskeletal network underlying the erthrocyte plasma membrane and determines cell shape, arrangement of transmembrane proteins and organization of organelles. It is expressed at very low levels in many tissues, with the strongest expression in the cerebellum, spinal cord, stomach, pituitary gland, liver, pancreas, salivary gland, kidney, bladder and heart. Spectrin beta 4 is a non-erythrocyte member, and is expressed in the brain and pancreatic islets and localisted to the nuclear matrix, cytoplasmic vesicles and PML nuclear bodies. Beta4 spectrins are also essential for membrane stability and the molecular organization of the nodes of Ranvier.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Spectrin beta-4
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone N393/2
Concentration 1 mg/mL
Conjugate PE
Formulation 2.48mM MES, 95.64mM phosphate with 2mM EDTA and no preservative; pH 7.4
Gene SPTBN4
Gene Accession No. Q9H254
Gene Alias 1700022P15Rik; 5830426A08Rik; beta-IV spectrin; beta-spectrin 4; dyn; EMBL BAB83243.1; KIAA1642; lnd; lumbosacral neuroaxonal dystrophy; neuroaxonal dystrophy; nmf261; nmf379; quivering; qv; ROSA62; SpbIV; spectrin beta 4; spectrin beta chain, brain 3; spectrin beta chain, non-erythrocytic 4; spectrin beta, non-erythrocytic 4; spectrin, beta, non-erythrocytic 4; spectrin, non-erythroid beta chain 3; SPNB4; SPTBN3; SPTBN4
Gene Symbols SPTBN4
Host Species Mouse
Immunogen Fusion protein amino acids 1621-1832 (C-terminal repeats 14 to 15) of human Beta4-spectrin.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 308458, 57731, 80297
Target Species Human, Mouse, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1
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