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Invitrogen™ SPEN Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA553388
Description
Immunogen sequence: NRERAYEHSA YGHHERGTGG FDRTRHYDQD YYRDPRERTL QHGLYYASRS RSPNRFDAHD PRYEPRAREQ FTLPSVVHRD IYRDDITREV RGRRPERNYQ HSRSRSPHSS QSRNQSPQRL ASQASRPTRS PSGSGSRSRS SSSDSI Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.
May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA.
Specifications
SPEN | |
Polyclonal | |
Unconjugated | |
SPEN | |
HIAA0929; KIAA0929; MINT; Msx2 interacting nuclear target (MINT) homolog; msx2-interacting protein; nuclear receptor transcription cofactor; RBM15C; SHARP; SMART/HDAC1-associated repressor protein; SPEN; spen family transcriptional repressor; SPEN homolog; spen homolog, transcriptional regulator | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
23013 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin), Immunocytochemistry | |
0.10 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q96T58 | |
SPEN | |
Recombinant protein corresponding to Human SPEN. Recombinant protein control fragment (Product #RP-91596). | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Safety and Handling
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