Invitrogen™ SPG7 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587745

Catalog No. PIPA587745

Description

Immunogen sequence: MAVLLLLLRA LRRGPGPGPR PLWGPGPAWS PGFPARPGRG RPYMASRPPG DLAEAGGRAL QSLQLRLLTP TFEGINGLLL KQHLVQNPVR LWQLLGGTFY FNTSRLKQKN KEKDKSKGKA PEEDEEERRR RERDDQMYRE RLRTLLVIAV VMSLLNALST SGGSISWNDF VHEMLAKGEV QRVQVVPESD VVEVYLHPGA VVFGRPRLAL MYRMQVANID KFEEKLRAAE DELNIEAKDR IPVSYKRTGF; Positive Samples: U-87MG, MCF7, HT-29, K-562, Mouse brain, Mouse kidney, Mouse liver; Cellular Location: Mitochondrion membrane, Multi-pass membrane protein.

This gene encodes a mitochondrial metalloprotease protein that is a member of the AAA family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. Mutations in this gene cause autosomal recessive spastic paraplegia 7. Two transcript variants encoding distinct isoforms have been identified.

Specifications

• Antigen: SPG7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SPG7
• Gene Alias: AI452278; AU015315; CAR; cell adhesion regulator; cell matrix adhesion regulator; CMAR; paraplegin; paraplegin, isoform 1; PGN; spastic paraplegia 7 (pure and complicated autosomal recessive); spastic paraplegia 7 homolog (human); spastic paraplegia 7 protein; SPG5C; SPG7; SPG7 matrix AAA peptidase subunit, paraplegin; SPG7, paraplegin matrix AAA peptidase subunit
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 234847, 6687
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.32 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q3ULF4, Q9UQ90
• Gene Symbols: SPG7
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human SPG7 (NP_0031101).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG