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Invitrogen™ SPHK1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA112719

Catalog No. 01-674-849


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Description

Description

A suggested positive control for this product is MDBK cell lysate.

SPHK1, along with SPHK2, catalyzes the phosphorylation of sphingosine producing the signaling molecule sphingosine-1-phosphate (S1P). S1P signals through G-protein coupled receptors and controls diverse cellular processes. Inhibitors of SPHKs are viewed as potential therapeutics for the treatment of cancer. SPHK1 catalyzes the phosphorylation of sphingosine to sphingosine 1 phosphate (S1P), an important signaling molecule with intra- and extracellular functions. Inside the cell S1P acts as a signaling molecule like other sphingolipid metabolites like ceramide and sphingosine. S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis. The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors).
TRUSTED_SUSTAINABILITY
Specifications

Specifications

SPHK1
Polyclonal
PBS with 0.08% sodium azide
Q8CI15, Q91V26, Q9NYA1
SPHK1
Synthetic peptide corresponding to the C-terminal of human Sphingosine Kinase 1.
100 μg
Primary
Human, Mouse, Rat, Bovine
Antibody
IgG
ELISA, Western Blot
Unconjugated
SPHK1
1110006G24Rik; Acetyltransferase SPHK1; RP23-193A16.4; SK 1; Sk1; SKase; Sphingosine kinase 1; SPHK; SPHK1; SPK; SPK 1; Spk1
Rabbit
Antigen Affinity Chromatography
RUO
170897, 20698, 618605, 8877
-20°C, Avoid Freeze/Thaw Cycles
Liquid
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