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Invitrogen™ SPHK1 Polyclonal Antibody
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Catalog No. 01674849
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100 μg
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Catalog No. Quantity
01-674-849 100 μg
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Catalog No. 01-674-849 Supplier Invitrogen™ Supplier No. PA112719
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Description

Rabbit Polyclonal Antibody

A suggested positive control for this product is MDBK cell lysate.

SPHK1, along with SPHK2, catalyzes the phosphorylation of sphingosine producing the signaling molecule sphingosine-1-phosphate (S1P). S1P signals through G-protein coupled receptors and controls diverse cellular processes. Inhibitors of SPHKs are viewed as potential therapeutics for the treatment of cancer. SPHK1 catalyzes the phosphorylation of sphingosine to sphingosine 1 phosphate (S1P), an important signaling molecule with intra- and extracellular functions. Inside the cell S1P acts as a signaling molecule like other sphingolipid metabolites like ceramide and sphingosine. S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis. The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors).
TRUSTED_SUSTAINABILITY

Specifications

Antigen SPHK1
Applications ELISA, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation PBS with 0.08% sodium azide
Gene SPHK1
Gene Accession No. Q8CI15, Q91V26, Q9NYA1
Gene Alias 1110006G24Rik; Acetyltransferase SPHK1; RP23-193A16.4; SK 1; Sk1; SKase; Sphingosine kinase 1; SPHK; SPHK1; SPK; SPK 1; Spk1
Gene Symbols SPHK1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to the C-terminal of human Sphingosine Kinase 1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 170897, 20698, 618605, 8877
Target Species Bovine, Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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