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Invitrogen™ SPHK1 Polyclonal Antibody
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Catalog No. PIPA587359
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100 μL
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PIPA587359 100 μL
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Catalog No. PIPA587359 Supplier Invitrogen™ Supplier No. PA587359
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: TLMLTERRNH ARELVRSEEL GRWDALVVMS GDGLMHEVVN GLMERPDWET AIQKPLCSLP AGSGNALAAS LNHYAGYEQV TNEDLLTNCT LLLCRRLLSP MNLLSLHTAS GLRLFSVLSL AWGFIADVDL ESEKYRRLGE MRFTLGTFLR LAALRTYRGR LAYLPVGRVG SKTPASPVVV QQGPVDAHLV PLEEPVPSHW TVVPDEDFVL VLALLHSHLG SEMFAAPMGR CAAGVMHLFY VRAGVSRAML LRLFLAMEKG RHMEYECPYL VYVPVVAFRL EPKDGKGVFA VDGELMVSEA VQGQVHPNYF WMVSGCVEPP PSWKPQQMPP PEEPL; Positive Samples: SW480, HeLa, Mouse kidney; Cellular Location: Cell membrane, Cytoplasm, Nucleus.

SPHK1, along with SPHK2, catalyzes the phosphorylation of sphingosine producing the signaling molecule sphingosine-1-phosphate (S1P). S1P signals through G-protein coupled receptors and controls diverse cellular processes. Inhibitors of SPHKs are viewed as potential therapeutics for the treatment of cancer. SPHK1 catalyzes the phosphorylation of sphingosine to sphingosine 1 phosphate (S1P), an important signaling molecule with intra- and extracellular functions. Inside the cell S1P acts as a signaling molecule like other sphingolipid metabolites like ceramide and sphingosine. S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis. The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors).
TRUSTED_SUSTAINABILITY

Specifications

Antigen SPHK1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.35 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene SPHK1
Gene Accession No. Q8CI15, Q9NYA1
Gene Alias 1110006G24Rik; Acetyltransferase SPHK1; RP23-193A16.4; SK 1; Sk1; SKase; Sphingosine kinase 1; SPHK; SPHK1; SPK; SPK 1; Spk1
Gene Symbols SPHK1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 50-384 of human SPHK1 (NP_0011360741).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20698, 8877
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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