Invitrogen™ SPHK1 Recombinant Rabbit Monoclonal Antibody (2L6P4)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA551350

Catalog No. FEMA551350

Description

Immunogen sequence: MDPAGGPRGV LPRPCRVLVL LNPRGGKGKA LQLFRSHVQP LLAEAEISFT LMLTERRNHA RELVRSEELG RWDALVVMSG DGLMHEVVNG LMERPDWETA IQKPLCSLPA GSGNALAASL NHYAGYEQVT NEDLLTNCTL LLCRRLLSPM NLLSLHTASG.

SPHK1, along with SPHK2, catalyzes the phosphorylation of sphingosine producing the signaling molecule sphingosine-1-phosphate (S1P). S1P signals through G-protein coupled receptors and controls diverse cellular processes. Inhibitors of SPHKs are viewed as potential therapeutics for the treatment of cancer. SPHK1 catalyzes the phosphorylation of sphingosine to sphingosine 1 phosphate (S1P), an important signaling molecule with intra- and extracellular functions. Inside the cell S1P acts as a signaling molecule like other sphingolipid metabolites like ceramide and sphingosine. S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis. The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors).

Specifications

• Antigen: SPHK1
• Classification: Recombinant Monoclonal
• Concentration: 0.203 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: Q9NYA1
• Gene Symbols: SPHK1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human SPHK1 (NP_001136074.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Format: Liquid

• Applications: ELISA, Western Blot
• Clone: 2L6P4
• Conjugate: Unconjugated
• Gene: SPHK1
• Gene Alias: 1110006G24Rik; Acetyltransferase SPHK1; RP23-193A16.4; SK 1; Sk1; SKase; Sphingosine kinase 1; SPHK; SPHK1; SPK; SPK 1; Spk1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8877
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid
• Isotype: IgG