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Invitrogen™ SPIB Monoclonal Antibody (4G5)
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Catalog No. PIMA517179
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100 μL
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Catalog No. Quantity
PIMA517179 100 μL
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Catalog No. PIMA517179 Supplier Invitrogen™ Supplier No. MA517179
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Description

Mouse Monoclonal Antibody

MA5-17179 targets SPIB in indirect ELISA, FACS, ICC, IHC, IF and WB applications and shows reactivity with Human and Mouse samples. The MA5-17179 immunogen is purified recombinant fragment of human SPIB (amino acids: 200-252) expressed in E. Coli. MA5-17179 detects SPIB which has a predicted molecular weight of approximately 28.8kDa.

Spi-B is a transcription factor belonging to a subfamily of ETS transcription factors with a conserved ETS domain that mediates specific DNA binding. Spi-B may form homotypic interactions and is known to interact with IRF4, CREBBP, EP300, SPI1/PU.1 related, JUN and TBP. As a sequence specific transcriptional activator it binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Two isoforms of Spi-B are reported. Spi-B is usually expressed in plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells and promotes their development and block viral replication. Spi-B is not expressed in T-cells or granulocytes but may be present in stem cell populations of the liver and B-cells where it helps in B-cell receptor (BCR) signaling, normal B-cell development and antigenic stimulation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SPIB
Applications ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 4G5
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation ascites with 0.03% sodium azide
Gene SPIB
Gene Accession No. O35906, Q01892
Gene Alias B42b-like; Ets transcription factor Spi-B; Spi-1/PU.1 related; Spib; SPI-B; Spi-B transcription factor; Spi-B transcription factor (Spi-1/PU.1 related); Transcription factor Spi-B
Gene Symbols SPIB
Host Species Mouse
Immunogen Purified recombinant fragment of human SPIB (amino acids: 200-252) expressed in E. Coli.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 272382, 6689
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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